Synthesis ofN-Fmoc-(2S,3S,4R)-3,4-dimethylglutamine: An Application of Lanthanide-Catalyzed Transamidation
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چکیده
منابع مشابه
Specificity of papain-catalyzed transamidation reactions.
In the experiments reported in the present communication, these studies have been extended with special reference to the specificity of the enzyme toward the dipeptide used as replacement agent. It had been suggested (1) that the value of pKz’ of a dipeptide is a determining factor in the efficiency with which it can participate in a transamidation reaction at ‘a given pH. This suggestion has b...
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Transamidation, or the conversion of one amide to another, is a long-standing challenge in organic synthesis. Although notable progress has been made in the transamidation of primary amides, the transamidation of secondary amides has remained underdeveloped, especially when considering aliphatic substrates. Herein, we report a two-step approach to achieve the transamidation of secondary aliphat...
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Transamidation reactions catalyzed by cathepsin C.
Previous publications from this laboratory (l-3) have described the catalysis of transamidation reactions by the proteinases papain, ficin, and crystalline chymotrypsin. In addition, preliminary experiments were reported on replacement reactions catalyzed by beef spleen cathepsin C, an intracellular endopeptidase of animal tissues, which resembles pancreatic chymotrypsin in its specificity. The...
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Most deoxyribozymes (DNA catalysts) require metal ions as cofactors for catalytic activity, with Mg(2+), Mn(2+), and Zn(2+) being the most represented activators. Trivalent transition-metal ions have been less frequently considered. Rare earth ions offer attractive properties for studying metal ion binding by biochemical and spectroscopic methods. Here we report the effect of lanthanide cofacto...
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ژورنال
عنوان ژورنال: The Journal of Organic Chemistry
سال: 2005
ISSN: 0022-3263,1520-6904
DOI: 10.1021/jo050518r